An introduction to the endogenous cannabinoid system .. glycerol is a full agonist through human type 2 cannabinoid receptor: antagonism by anandamide . May 16, All these systems make up the human body. the first to describe the structure and functional expression of the cannabinoid receptor, CB The endocannabinoid system (ECS) is a biological system composed of endocannabinoids, . In humans, cannabinoid receptors exist in much lower concentration in these regions, which helps explain why cannabinoids possess a greater.
Cannabinoid The System Human
Most recently, CB1 has been isolated in tissues that are important for energy metabolism such as the liver, adipose fat tissue and skeletal muscle. Cannabinoid receptors act as binding sites for endogenous cannabinoids as well as cannabinoids found in marijuana. When cannabinoids bind to CB1 or CB2 receptors, they act to change the way the body functions.
Cannabinoids exert their effects by interacting with cannabinoid receptors present on the surface of cells in different parts of the central nervous system. They also differ in their sensitivity to agonists and antagonists. Evidence suggests that additional cannabinoid receptor types may exist. The discovery of the cannabinoid receptors CB! These naturally endogenous ligands or cannabinoids bind to the CB1 and CB2 receptors. Many other endocannabinoids that can activate CB receptors, such 2-AG, have since been discovered.
Evidence has emerged that the endocannabinoid ligands are synthesized on demand rather than stored; the endocannabinoid system is transiently activated under certain stressful conditions to restore homeostasis.
THC has analgesic, anti-spasmodic, anti-tremor, anti-inflammatory, appetite stimulant and anti-emetic properties. CBD has anti-inflammatory, anti-convulsant, anti-psychotic, anti-oxidant, neuroprotective and immunomodulatory effects. As an annual, cannabis plants follow a solar cycle consisting of two basic stages often referred to as vegetative, and bloom.
Cannabinoids are created in the bloom phase. In general, there are three different types of endocannabinoids:. The cannabinoids interact with the receptors, much like a lock and key. First, immune cells detect the presence of bacteria and release pro-inflammatory molecules that tell other immune cells to come and join the fight. By tightly regulating inflammation, the immune system can destroy germs or remove damaged tissue, and then stop.
This prevents excessive inflammation, allowing cells, and thus the body, to return to the Goldilocks zone. The reason that plant cannabinoids have psychoactive and medicinal effects within the body is, in large part, because we have an endocannabinoid system ECS that they can interact with. Endocannabinoids like anandamide also activate CB1. A couple big reasons. The plant-based cannabinoid CBD illustrates this nicely, as it interacts with numerous receptor types in the brain.
So, while plant cannabinoids may activate the same cannabinoid receptors as endocannabinoids, they will likely interact with several other receptors and therefore have distinct effects.
The endocannabinoid system ECS , comprised of cannabinoid receptors, endocannabinoid molecules, and their metabolic enzymes, is a crucial molecular system that the body uses to help maintain homeostasis.
Like any other complex biological system, the ECS can go awry. By understanding the biological Goldilocks principle homeostasis , and how the ECS illustrates this at the cellular level, we can more deeply appreciate why we have an ECS to begin with, and how a variety of cannabis-based therapies might actually work. The presence and critical function of the ECS across many systems of the body, including the nervous and immune systems, explains why such a wide variety of ailments and disease states are responsive to cannabis-based interventions.
The discovery of the endocannabinoid system ECS is the single most important scientific medical discovery since the recognition of sterile surgical technique. As our knowledge expands, we are coming to realize that the ECS is a master control system of virtually all physiology. The total effect of the ECS is to regulate homeostasis and prevent disease and aging. The more we learn, the more we realize that we are in the infancy of this scientific field of study. The ECS is a control system which involves tissue receptor proteins, cellular communication and control, molecular anatomy and the scavenging of oxygen free radicals.
This new field of science will change medicine forever and prove cannabis the gold standard for many disease processes. Its effect on scavenging oxygen free radicals is applicable to all disease processes and this is why it has such wide medical application and is considered a cure-all by many. The discovery of the ECS will replace the current medical system of managing and treating disease.
Instead of management of symptoms after disease has occurred, we will prevent disease and cancer by manipulation of the ECS. Research and education of medical students involving the ECS is being intentionally restricted by politics. No justification can be made for the restriction of the scientific study of cannabis and the endocannabinoid system.
What is the danger of providing government-grown and tested cannabis to researchers? Diversion of research cannabis for non-scientific or recreational purposes does not seem to be a serious threat to national security.
Feel free to point out the folks who were mean to you…. Interesting study you carried out and very true. Even spell check tries to correct you when you type endocannabinoid system. Go ahead type endocannabinoid and it will suggest endocrinologist. Every time I tried to type it, it would not even be acknowledged. ECS homeostasis — yes, yes, yes. I like the main pic used for the article; balance.
Now, using cannabinoids as sedation agents — THAT creates a very safe yet very profound imbalance. There are very few, if any, CB1 receptors in the medulla oblongata, while in the cerebellum there are an abundance. SO, if you flood the system with cannabinoids, especially THC, you fall down and go to sleep — quickly — and very safely. I should know, I tested such on myself in — and had my first patent recently allowed protecting the innovation.
So yes, we have a ton to learn some catching-up to do. Great information and article! Content failed to load. Country United States Canada. Sorry, you're not old enough to visit Leafly.
The Science of the Endocannabinoid System: How THC Affects the Brain and the Body
Cannabinoid science. Medical marijuana research led to the discovery of The Endocannabinoid System, an important system in the human body. Dec 16, The endocannabinoid system plays many crucial roles in your body, and " Cannabinoid" comes from "cannabis," and "endo" is short for. Mar 7, Most people however, are unaware that the human body has its own system for processing and even creating its own cannabinoids known as.