Cannabinoids can treat an array of skin conditions, according to a research review recently published in the Journal of the American Academy. Cannabinoids may soothe certain skin diseases, say researchers containing cannabinoids may be effective against eczema, psoriasis, atopic for cannabinoids is in the treatment of itch," said the study's senior author Dellavalle said for those who have used other medications for itch and skin disease. Marijuana may be useful in treating symptoms related to skin diseases including eczema and psoriasis, according to research. health-related issues, researchers are focusing on the four other agents, or cannabinoids, found.
Other Eczema, and Soothe Skin Cannabinoids Psoriasis, Diseases Study:
Some topical cannabinoid products, specifically those containing higher levels of THC, are only legally available in states with a prescription and in states with medical cannabinoid laws. Others, such as CBD topicals that use oil derived from hemp, are legal under federal law individual states may pass laws governing hemp-derived CBD. You can learn more about the laws regarding CBD here. Want to learn more about the therapeutic properties of cannabinoids?
Federal Tax ID The information contained in this website is for general information and educational purposes only. According to the researchers, current literature suggests that cannabis might be an effective treatment for a variety of skin disorders, particularly pruritus - a condition characterized by severe itching.
As an example, the team points to one study whereby 21 adults with pruritus applied a cannabinoid cream twice daily for 3 weeks. Eight of the adults experienced complete eradication of pruritus as a result. Other studies suggest that cannabinoids might also be effective for the treatment of melanoma; the team cites studies that identified a decrease in tumor growth in melanoma mouse models following injection with THC. The researchers also uncovered studies that showed that THC reduced inflammation in mice, which indicates that the skin health benefits of cannabinoids might be down to their anti-inflammatory properties.
Dellavalle warns that the majority of studies included in this review involved animal models, and large-scale clinical trials assessing the safety and efficacy of topical cannabinoids for skin diseases in humans have yet to be conducted.
However, he notes that the current evidence suggests that patients with skin diseases who fail to respond to conventional treatments might benefit from topical cannabinoid therapies. When it comes to melanoma, however, Dr. Dellavalle says that he does not recommend topical cannabinoids as a treatment based on current findings. MNT is the registered trade mark of Healthline Media. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional.
Privacy Terms Ad policy Careers. This page was printed from: Get the most out of Medical News Today. Subscribe to our Newsletter to recieve: Professionally-verified articles Daily or weekly updates Content custom-tailored to your needs Create an account. More Sign up for our newsletter Discover in-depth, condition specific articles written by our in-house team. However, despite the misleading advertising often used to market such products, hemp seed oil does not contain cannabinoids or other bioactive phenolic compounds, and its therapeutic effect goes no further than any other preparation containing polyunsaturated fatty acids and favouring skin hydration.
However, to judge from pre-clinical studies, cannabinoids also have great potential for therapeutic management of AD Ong PY, ; Wollenberg and cols, In this regard, selective CB1R agonists inhibit the activation of mastocytes and the release of histamine.
Moreover, topical application of anandamide analogs has been shown to reduce skin inflammation in animal models of AD Kim et al. Other authors have suggested that CB1R expression in keratinocytes plays a relevant role in maintaining the epidermal barrier Gaffal et al.
Finally it has also been described that the release of histamine from CB2R inhibits the inflammatory skin reaction mediated by IgE and intense spontaneous pruritus in AD Maekawa et al. The antibacterial action of Cannabis sativa preparations and phytocannabinoids has been well known for decades, although only more recently has the antibacterial activity of cannabinoids THC, CBD, CBG and their precursors acid forms against methicillin-resistant staphylococcus been demonstrated Appendino et al.
The cannabinoids and other types of compound are thought to have interacting synergic effects. This would explain why in some in vitro studies, better results have been obtained with extracts from the plant than with pure isolated compounds.
Although the content of cannabinoids and other types of compound varies depending on the variety of plant, cannabinoids can be said to have huge potential for treating AD, given their anti-inflammatory and antibacterial properties. Systemic scleroderma or sclerosis SSc is a rare autoimmune disease that has three main characteristics: SSc is characterised by progressive thickening and fibrosis of the skin, secondary to excessive accumulation of collagen, which can be limited to the skin localised —or limited— cutaneous SSc or extend to internal bodies diffuse SSc.
SSc begins with a microvascular injury and inflammation. This is followed by fibroblast activation, a key event in the development of fibrosis. Recent evidence shows that genetic and pharmacological manipulation of the endocannabinoid system modulates the fibrotic response. CB1 and CB2 receptors, too, have shown different patterns in experimental models of dermal fibrosis.
Blockage of CB1R prevents activation of fibroblasts and has a powerful antifibrotic effect Marquart et al. The role of CB1R as a profibrotic receptor has also been confirmed in knock-out mice for FAAH, in which high levels of endocannabinoids can induce fibrosis through a CB1R-dependent path. On the other hand, activation of CB2R prevents cutaneous fibrosis and the infiltration of tissue leukocytes in models of experimental dermal fibrosis Akhmetshina et al. This concurs with the fact that the CB2R knock-out mice are more susceptible to the development of fibrosis Balistreri et al.
The cannabinoid receptor CB2 exerts antifibrotic effects in experimental dermal fibrosis. Arthritis and rheumatism ; Antibacterial cannabinoids from Cannabis sativa: The cannabinoid WIN55, abrogates dermal fibrosis in scleroderma bleomycin model. Annals of the rheumatic diseases ; Derakhshan N, Kazemi M. The cannabinoid quinol VCE
6 Eye-Opening Ways Cannabis Benefits Your Skin
A new study finds that cannabinoids may help help soothe eczema, psoriasis, dermatitis, and even skin cancer, among other diseases. If you suffer from skin diseases, you know relief can be a rare find. According to a recent study published in Pharmacognosy Reviews, which deals Cannabis sativus] is useful for treatment of eczema and host of other skin. Cannabis oil could help treat eczema and psoriasis, scientists say some sort of skin condition and, for many, finding a cure can be hard work. suffer with eczema or psoriasis, after new research shows cannabis to have a.